MGMT UNDEREXPRESSION Detail (hg38) (MGMT)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr10:131,265,448-131,566,271 View the variant detail on this assembly version. |
| hg38 | chr10:129,467,184-129,768,007 |
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
| Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| glioblastoma | Temozolomide | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
3 | 17442989 | Detail |
| high grade glioma | Temozolomide | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
3 | 21365007 | Detail |
| oligodendroglioma | Temozolomide | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
2 | 16541434 | Detail |
| glioblastoma | Temozolomide | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
3 | 21331613 | Detail |
| neuroendocrine tumor | Temozolomide | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
2 | 19118063 | Detail |
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| In this study, patients with low MGMT expression, compared with patients with high MGMT expression, ... | CIViC Evidence | Detail |
| This study showed that low MGMT mRNA expression was strongly predictive for prolonged time to progre... | CIViC Evidence | Detail |
| In this study, loss of chromosome 1p and low MGMT protein expression were associated with objective ... | CIViC Evidence | Detail |
| In 41 glioblastomas treated with temozolomide (TMZ) therapy (MGMT-immunopositive: n = 22, negative: ... | CIViC Evidence | Detail |
| Among those patients who received temozolomide-based therapy in this study, the median progression-f... | CIViC Evidence | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- MGMT
- Genome
- hg38
- Position
- chr10:129,467,184-129,768,007
- Variant Type
- cnv
- Variant (CIViC) (CIViC Variant)
- UNDEREXPRESSION
- Transcript 1 (CIViC Variant)
- ENST00000306010.7
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/1255
Genome browser